Membrane fishing for HIV-neutralizing antibodies
نویسندگان
چکیده
منابع مشابه
Broadly Neutralizing Antibodies for HIV Eradication.
Passive transfer of antibodies has long been considered a potential treatment modality for infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV replication, however, were largely unsuccessful, as the antibodies that were studied neutralized only a relatively narrow spectrum of viral strains and were not very potent. Recent advances have led to the discovery of a l...
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The membrane-proximal external region (MPER) of the HIV-1 gp41 consists of epitopes for the broadly cross-neutralizing monoclonal antibodies 2F5 and 4E10. However, antigens containing the linear sequence of these epitopes are unable to elicit potent and broad neutralizing antibody responses in vaccinated hosts, possibly because of inappropriate conformation of these epitopes. Here we designed a...
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A dvances in technology—especially single-cell antibody cloning techniques—have led to the isolation and characterization of antibodies from people with HIV infection that can neutralize many variants (1). These are referred to as broadly neutralizing antibodies (bnAbs). Such antibodies can be detected in about 25% of persons with untreated HIV-1 infection (2), reflecting a host immune response...
متن کاملHIV vaccine development and broadly neutralizing antibodies
Human immunodeficiency virus-1 (HIV-1) infects about 35 million people worldwide [1]. There is no vaccine in current clinical use. Although available drug treatments are generally effective in controlling infection, they are not curative, can cause significant side effects and are unable to prevent comorbidities such as cardiovascular disease and cancers. In 2012, about 1.6 million people world...
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The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an e...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2012
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.2367